Study on HLA alleles and haplotypes of 572 patients with acute lymphoblastic leukemia in southern Chinese Han
10.3760/cma.j.issn.1009-9921.2009.01.003
- VernacularTitle:中国南方汉族急性淋巴细胞白血病患者572例的HLA基因和单倍型分析
- Author:
Suqing GAO
;
Lianghong CHENG
;
Liang LU
;
Jiacai ZHUO
;
Ming LI
;
Shizheng JING
;
Hongyan ZOU
;
Zhihui DENG
- Publication Type:Journal Article
- Keywords:
Leukemia,lymphoblastic,acute;
HLA antigens;
Genes;
Haplotype
- From:
Journal of Leukemia & Lymphoma
2009;18(1):9-11,14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the distributive characteristics of HLA-A,B,DRBI alleles and haplotypes patients with ALL in southern Chinese Han.Methods The frequencies of HLA-A,B,DRB1alleles and haplotypes were estimated by Expectation-Maximization method based on the genotypes of 572patients with ALL and 5645 unrelated health donors,and then compared by chi-square test.Results The frequencies of HLA-A33(7.15%vs 9.3%,OR=0.73,P＜0.05),B58(5.93%vs 8.75%,OR=0.64,P＜0.05),DRB1*17(5.15%vs 6.30%,OR=0.82,P＜0.05)alleles and HLA-A33-B58-DRB1*17(2.46%vs 4.14%,OB=0.35,P＜0.05)haplotype were significantly lower in ALL patient groups than that in controls.The frequencies of HLA-A3(2.1%vs 1.26%,OR=1.7,P＜0.05),B51(7.25%vs 5.78%,OR=1.3,P＜0.05)and DRB*12 (16.13%vs 12.99%,OR=1.35,P＜0.05)alleles and A2-B51-DRB1*12(1.24%vs.0.89%,OR=1.66,P＜0.05)haplotype were significantly higher in ALL patient groups than that in controls.Conclusion These results indieated that HLA-A33-B58-DRB1*17 haplotype was a associated with a diminished incidence of ALL.and HLA-A3 auele or A2-B51-DRB1*12 haplotype was weakly associated with ALL.
