The significance of protein C in acute leukemia patients with disseminated intravascular coagulation

VernacularTitle:蛋白C检测在急性白血病合并弥散性血管内凝血中的意义
Author: Ruijuan ZHANG ; Xiue LIU ; Linhua YANG ; Bin YU
Publication Type:Journal Article
Keywords: Leukemia,promyelocytic,acute; Leukemia,lymphocytic,acute; Leukemia,myelocytic,acute; Disseminated intravascular coagulation; Proteins C; Diagnosis
From: Journal of Leukemia & Lymphoma 2008;17(2):108-109,113
CountryChina
Language:Chinese
Abstract: Objective To investigate diagnostic and prognostic significance of protein C in acute leukemia with disseminated intravaseular coagnlation(DIC). Methods APTT, P-T, D-Dimer, Fbg, antithrombin (AT) and protein C(PC) were determinated in plasma of 44 DIC patients with acute leukemia and 30 normal controls. Results PC was markedly lower in disseminated intravaseular coagulation with acute leukemia group(67.03±36.98) than that of control group (99.53±45.20), and significantly correlation DIC score( r = -0.57,P＜0.01). PC of abnormality rate in DIC group was 86.36 %. APTT, PT, D-Dimer, Fbg were significantly increased and AT was decreased during the progress of DIC in relation to values observed in the control group. Conclusion DIC is related to the disorder of coagulation and fibfinolysis system. PC is a sensitive index to diagnose and prognose DIC in acute leukemia.