Correlation and expression of Ki-67, VEGF and p27 expressed in patients with acute leukemia
10.3760/cma.j.issn.1009-9921.2009.02.011
- VernacularTitle:Ki-67、VEGF和p27在急性白血病中的表达及其相关性研究
- Author:
Juan ZHU
;
Yanfang LIU
;
Hui SUN
;
Qiuhong WANG
;
Lijie HAN
- Publication Type:Journal Article
- Keywords:
Leukemia,acute;
Ki-67 antigen;
Vascular endothelial growth factors;
Cyclindependent kinase inhibitor p27
- From:
Journal of Leukemia & Lymphoma
2009;18(2):96-97,101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role and their relationship of Ki-67, VEGF and p27 expressed in adult patients with acute leukemia. Methods The expression of Ki-67, VEGF and p27 in bone marrow mononuclear cells (BMMNC) were analyzed by immunocytochemical staining, and their correlations of Ki-67, VEGF and p27 were statistically analyzed. Results The expression of Ki-67(42.48±25.78)% or VEGF (44.89±24.01)% on BMMNC from acute leukemia cells was significantly higher than that in the control (11.40±9.94)% or (16.90±12.54)% (P<0.01). But the expression of p27 (23.65±13.30)% was significantly lower than that in the control (50.23±22.68)% (P<0.01). The expressions of Ki-67 were positively correlated with and VEGF in patients with acute leukemia were positively correlated(r=-0.666, P<0.01), and the expressions of Ki-67 and p27 were negatively correlated with p27 in patients with acute leukemia (r=-0.316, P<0.05).Conclusion The evaluation of expression of Ki-67, VEGF and p27 on acute leukemic cells provides new insights to the pathogenesis is helpful in mechanism and is helpful in the diagnosis of acute leukemia.
