Correlation between peripheral blood CD+4CDhigh25CDlow127 regulatory T cell and clinical characteristics of patients with non-Hodgkin's lymphom
10.3760/cma.j.issn.1009-9921.2012.04.007
- VernacularTitle:非霍奇金淋巴瘤患者外周血CD+4CDhigh25CDlow127调节性T细胞水平与其临床特点的关系
- Author:
Lieyang WANG
;
Zhiqiang ZHAO
;
Yanfeng WANG
;
Wen SU
;
Yuping ZHENG
- Publication Type:Journal Article
- Keywords:
Lymphoma,non-Hodgkin;
T-lymphocytes,regulatory
- From:
Journal of Leukemia & Lymphoma
2012;21(4):218-220,224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between CD+4CDhigh25CDlow127 Treg level of peripheral blood and NHL.Methods The level of peripheral blood CD+4CDhigh25CDlow127 Treg of 123 newly diagnosed NHL and 41 healthy adults were test by flow cytometry.Results The average peripheral blood CD+4CDhigh25CDlow127 Treg level were 5.0 ％ (2.7 ％) and 7.2 ％(3.8 ％) in healthy adults and newly diagnosed NHL patients,respectively.The difference between the two groups was statistically significant(Z=-2.816 P=0.001 ).The peripheral blood Treg level was significantly higher in the male NHL patients than that in the female (7.4％ vs 6.1％,Z=- 2.729,P=0.006).The peripheral blood Treg level was significantly higher in elevated LDH patients than that in normal LDH patients(7.8％ vs 7.0％,Z=-2.623 P=0.008).The peripheral blood Treg level was significantly higher in stage Ⅲ-Ⅳ patients than that in stage Ⅰ -Ⅱ patients (7.3％ vs 5.9％,Z=-2.057 P=0.04). There was no significant relationship between peripheral blood Treg level and age, IPI score,extranodal involvement,performance status,bulky disease,pathologic subtype or B symptom (P ＞0.05).Conclusions NHL patients are in an immunosuppresive statue.Patients of male,with inreased LDH level or in stage Ⅲ-Ⅳ have higher peripheral blood CD+4CDhigh25CDlow127 Treg level.
