Expression of MIB1 and Topo Ⅱα and their relation with prognosis

VernacularTitle:MIB1与TopoⅡα在弥漫大B细胞淋巴瘤的表达及其与预后的关系
Author: Shan WANG ; Jinfen WANG ; Guoping WANG
Publication Type:Journal Article
Keywords: Lymphoma,large-cell,diffuse; Immunohistochemistry; Ki-67 antigen; DNA topoisomerases,type Ⅱ; Prognosis
From: Journal of Leukemia & Lymphoma 2008;17(5):367-368,371
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of MIB1 and Topo Ⅱα,and their relation to the clinical grades and biological behavior in diffuse large-B cell lymphoma(DLBCL).Methods 66 csses of DLBCL were selected from the Pathological Department of Shanxi Tumor Hospital from 1996 to 2001.An ABC method was used to detect the expression of CD3,CD20,CD79α,Pax5,and a double immunostaining technique ABC-DAB/SABAP-vector red and ABC-DAB/immunogolden was used to detect the expression of MIB1 and Topo Ⅱα.Results Expression of MIB1 and Topo Ⅱα were increased along with the clinical stage of the DLBCL.There was a significant difference between ealier stage(Ⅰ,Ⅱ)and later stage(Ⅲ,Ⅳ)in DLBCL(P＜0.05).The expression of MIB1 and Topo Ⅱα were also significantly related to the survival rate(r=-0.487,0.251 respectively,P＜0.05).Conclusion Expression of MIB1 and Tope Ⅱα may serve as two independent prognostic predictors in DLBCL.