Expression of Transforming Growth Factor-β Isoforms in Colonic Mucosa of Patients with Ulcerative Colitis
10.3969/j.issn.0253-9896.2010.03.014
- VernacularTitle:转化生长因子-β亚型在溃疡性结肠炎患者结肠黏膜中的表达
- Author:
Lianpeng ZHENG
;
Hua YIN
;
Zongshun Lü
- Publication Type:Journal Article
- Keywords:
colitis,ulcerative;
transforming growth factor beta;
immunohistochemistry;
intestinal mucosa;
colonic diseases,functional
- From:
Tianjin Medical Journal
2010;38(3):201-203,后插3
- CountryChina
- Language:Chinese
-
Abstract:
Objoctive:To investigate the expression of transforming growth factor-β(TGF-β)isoforms in colonic mucosa of ulcerative colitis(UC),and its role in the incidence of UC thereof.Methods:The expression of TGF-β isoforms was detected in colonic mucosa by immunohistochemical Envision method in UC patients,and the patients with irritable bowel syndrome (IBS)were used as controls.The relationship was analyzed between the expression of TGF-β isoforms and the degree of severity and extent of the disease.Results:There were statistical differences in the expression of TGF-β1 and TGF-β2 between the active stage UC,remission stage UC and IBS groups(P ＜ 0.01).The expression was significantly higher in active stage UC group than that in remission stage UC and 1BS groups(P＜ 0.01).The expression was significantly higher in remission stage UC group than that in IBS group(P ＜ 0.01).However,there was no statistical difference in the expression of TGF-β3 between active stage UC,remission stage UC and IBS groups(P＞ 0.05).The expression of TGF-β1 and TGF-β2 had positive correlation with the degree of sevefity(P ＜ 0.05).However,the expression of TGF-β3 had no linear correlation with the degree of severity(P ＞ 0.05).There was no linear correlation on the expressions of TGF-β1,TGF-β2 and TGF-β3 with extent of the disease(P ＞ 0.05).The degree of severity had positive correlation with extent of the disease(P ＜ 0.05).Conclusion:The expressions of TGF-β1 and TGF-β2 were enhanced in colonic mucosa of UC,and were correlated with the pathogenesis of UC.The expressions of TGFβ1 and TGF-β2 may serve as markers for assessing disease activity of UC.
