Second allogeneic hematopoietic stem cell transplant from one sibling donor for a patient with acute myeloid leukemia relapsed after the first transplantation
10.3760/cma.j.issn.1009-9921.2010.06.012
- VernacularTitle:急性髓系白血病患者异基因骨髓移植后复发行同一供者二次移植一例
- Author:
Kai FENG
;
Fuguang YE
;
Yiwei XU
;
Ming JIANG
;
Hu CHEN
;
Bingyi SHI
- Publication Type:Journal Article
- Keywords:
Leukemia,acute;
Hematopoietic stem cell transplantation;
Transplantation,homologous
- From:
Journal of Leukemia & Lymphoma
2010;19(6):355-356,379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of second allogeneic hematopoietic stem cell transplantation (allo-HSCT) for treatment of leukemia relapsed after first allo-HSCT from one sibling donor.Methods One patient with acute myeloid leukemia (AML-M4) underwent sibling donor bone marrow transplant (conditioning regimens was Bu/Cy) and relapsed after 18 months. The patient received the same donor's peripheral blood stem cell (PBSC) for second transplantation after receiving CY-TBI regimens,and reduced intension of prophylaxis of GVHD. Results The patient achieved stable engraftment after second HSCT. The patients suffered acute GVHD (intestinal Ⅳ and cutaneous Ⅲ) and had been complete remission to +8 months. Conclusion Second related HSCT is feasible in relapsed patient who had undergone related allo-BMT.
