Diagnosis and treatment of four patients with myeloproliferative neoplasms and a literature review
10.3760/cma.j.issn.1009-9921.2010.10.005
- VernacularTitle:骨髓增殖性疾病四例并文献复习
- Author:
Wanling SUN
;
Bingxin JI
- Publication Type:Journal Article
- Keywords:
Myeloproliferative disorders;
Diagnosis;
Therapy
- From:
Journal of Leukemia & Lymphoma
2010;19(10):590-592,603
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical practice of the diagnosis and treatment of four patients with myeloproliferative diseases (MPD) and review the relative literatures. Methods The progress of diagnosing and treating one polycythemia vera patient, two essential thrombocythemia patients and one primary myelofibrosis patient were introduced. Results Interferon alone, interferon combined with hydroxyurea and HLA matched sible allogeneic hematopoietic stem cell transplantation were carried out separately, the satisfying outcomes were shown. Conclusion Detection of genetic mutation of JAK2 V617F has markedly facilitated the approach to clinical diagnosis of MPD. The therapeutic aim for patients with polycythemia vera and essential thrombocythemia is preventing the occurrence thromboembolic events, while for some high-risk primary myelofibrosis patient, allogeneic stem cell transplantation should be considered.
