Study on the transcription level of new tumor suppressor gene SLC5A8 mRNA in colorectal cancer tissues
10.3760/cma.j.issn.1673-4203.2015.05.010
- VernacularTitle:新肿瘤抑制基因SLC5A8在结直肠癌组织中mRNA转录水平的研究
- Author:
Na CHEN
;
Xiaoshi JIN
;
Zhengwei JIAO
;
Shujie CHENG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
SLC5A8;
Gene,tumor suppressor;
RT-qPCR;
RNA transport;
Gene expression
- From:
International Journal of Surgery
2015;42(5):317-320,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the transcription level of new tumor suppressor gene SLC5A8 mRNA in colorectal cancer tissues.Methods Collected specimens of 23 cases with colorectal cancer and cut out carcinoma tissues and Pericarcinomatous tissue respectively,then used real time fluorescent quantitative PCR (RT-qPCR)to detect the transcription level of gene SLC5A8 mRNA,and the results of carcinoma tissues and pericarcinomatous tissues were analyzed by t test.Results The transcription level of new tumor suppressor gene SLC5A8 mRNA in colorectal cancer tissues is significantly lower than pericarcinomatous tissue (P =0.002).Conclusion The expression of gene SLC5A8 in colorectal cancer tissues is declining or missing,suggesting it has a certain relationship with the incidence of colorectal cancer.
