Prevention of aseptic loosening prothesis of alendronate in beagle:abiomechanical study

VernacularTitle:阿仑膦酸钠预防比格犬人工假体松动的生物力学研究
Author: Hai MENG ; Songhua YAN ; Lin YANG ; Ai GAO
Publication Type:Journal Article
Keywords: Alendronate; Aseptic loosening prothesis; Biomechanics; Placebos; Joint prosthesis
From: International Journal of Surgery 2015;42(5):314-316,封3
CountryChina
Language:Chinese
Abstract: Objective To investigate effect of alendronate on prevention of aseptic loosening prothesis.Method Twelve beagles which had been implanted a titanium plug in femur were divided into two groups randomly,one received alendronate,and the other placebo as control.After 12 weeks,all beagles were sacrificed.specimens of femur were studied by biomechanical test.Independent sample t test was used for statistical analyses.Results The pull-out strength of the experimental group was higher than that of the control (P ＜ 0.05),and the torsion strength was also higher in the experimental group(P ＜ 0.05).Conclusion The therapy of alendronate can change the bone strength,inhibit aseptic loosening of prosthesis in beagle and could be a good drug for the prevention and treatment of aseptic loosening prothesis.