Expression and clinical signifcance of TROP2 and MMP-9 in cholangiocarcinoma
10.3760/cma.j.issn.1673-4203.2015.02.009
- VernacularTitle:滋养层细胞表面抗原2与MMP-9在胆管癌中的表达和临床意义
- Author:
Tongjun ZHANG
;
Dong XUE
;
Guoxiang QU
;
Xinjun LI
;
Xianyong ZHOU
;
Piguang CHENG
;
Chengde ZHANG
- Publication Type:Journal Article
- Keywords:
Bile duct neoplasms;
Trophoblast cell-surface antigens 2;
Matrix metalloproteinase 9;
Immunohischemistry
- From:
International Journal of Surgery
2015;42(2):101-105,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of TROP2 and MMP-9 protein expression in cholangiocarcinomas and their relationship between the pathological behavior and prognosis.Methods A total of 54 patients who were diagnosed with cholangiocarcinoma in the People's Hospital of Binzhou,were retrospectively reviewed.Immunohistochemical staining and Log rank test were used to detect the expression of TROP2 and MMP-9 protein in 54 cases of cholangiocarcinomas and 18 cases of normal bile duct tissues achieved by partial hepatectomy of hepatolithiasis.Results The positive expression rate of TROP2 in cholangiocarcinoma tissues (55.6％) was higher than that of normal bile duct tissues (5.6％).The positive expression rate of MMP-9 in cholangiocarcinoma tissues (51.9％) was higher than that of normal bile duct tissues (11.1％).The differences of the expression of TROP2 and MMP-9 in cholangiocarcinoma of TNM stage,lymph node metastasis and neural invasion were significant(all P ＜ 0.05).There was significant positive correlation between TROP-2 and MMP-9 expression by using spearman correlation analysis (r =0.555,P ＜ 0.001).Survival analysis showed that TROP2 expression was an independent prognostic factor in cholangiocarcinoma.Conclusions TROP2 plays a important role in the development and metastasis of cholangiocarcinoma.Thus,TROP2 may be a prognostic indicator for cholangiocarcinoma.
