Establishment and characterization of human colorectal cancer orthotopic implantation model in nude mice
10.3760/cma.j.issn.1673-4203.2015.02.006
- VernacularTitle:人结直肠癌裸鼠原位移植模型的建立及生物学特性的研究
- Author:
Tangsakar ERMEK
;
Yang WANG
;
Yina WANG
;
Jiansheng WANG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Orthotopic implantation;
Models,animal;
PCNA;
Survivin;
Immunochemistry
- From:
International Journal of Surgery
2015;42(2):90-92,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish and characterize human colorectal cancer orthotopic implantation model in nude mice.Methods Established the human colorectal cancer orthotopic implantation model by surgery,characterize its biological characteristics by immunohistochemistry.Results Human colorectal cancer orthotopic implantation model was established in nude mice successfully,the proliferating cell nuclear antigen and Survivin were overexpressed in the models which were simulated the characteristics of human colorectal cancer perfectly.Conclusion This human colorectal cancer orthotopic implantaion model will provide an excellent animal model for us to study the development and metastasis mechanism of human colorectal cancer.
