Analysis of XRCC1 and TYMS gene polymorphism test results of resected non-small cell lung cancer

VernacularTitle:手术切除的非小细胞肺癌XRCC1和TYMS基因多态性检测结果分析
Author: Yong CUI ; Bingqun WU ; Xinchun DUAN ; Guan SHI ; Dong CHANG ; Min GONG
Publication Type:Journal Article
Keywords: Carcinoma,non-small-cell-lung; Tumor markers,biological; Adjuvant chemotherapy,individualized chemotherapy
From: International Journal of Surgery 2015;42(1):26-29,后插1
CountryChina
Language:Chinese
Abstract: Objective To discusses the clinical significance of XRCC1 399 and TYMS 5'-translation section enhancement subsequence polymorphism in guidance the postoperative individual chemotherapy for patients with resected non-small cell lung cancer.Methods Retrospectively analyze the results of 150 cases from February 2010to June 2014.Statistical analysis with SPSS 21.0.Results Three of the most common gene type of XRCC1 399 is Arg/Arg(58.7％),Arg/Gln(36.7％) and Gln/Gln(4.6％),respectively.Three of the most common gene type of TYMS is 3R/3R (70.7％),2R/3R (25.3％) and 2R/2R (4.0％),respectively.Conclusion In resected non-small cell lung cancer,XRCC1 399 Arg/Arg genotype is the most common,followed by Arg/Gln type.At the sarne time,TYMS gene type 3R/3R accounted for more than 70％,especially higher percentage of in adenocarcinoma.Neither of these two gene polymorphism is recommended as marker to guide the postoperative individual chemotherapy.