Causal genes and pathways analysis of juvenile idiopathic arthritis
10.3760/cma.j.issn.1673-4181.2015.02.010
- VernacularTitle:幼年特发性关节炎的致病基因与通路分析
- Author:
Hui LI
;
Zhanlei SHI
;
Shuai YANG
;
Shunyi WANG
- Publication Type:Journal Article
- Keywords:
Gene microarray;
Juvenile idiopathic arthritis;
Bioinformatics
- From:
International Journal of Biomedical Engineering
2015;38(2):104-106,后插2
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pathogenesis of juvenile idiopathic arthritis (JIA) and its potential molecular targets.Methods Gene microarray data about JIA was downloaded from Gene Expression Omnibus (GEO) in NCBI.Different expressed genes were identified through bioconductor packages in R programing.The causal genes from the different expressed genes were optimized and replenished by GLAD4U and ToppGene.Functional annotation information of causal genes was carried out by DAVID.Results List of causal genes was obtained as well as their enriched function.Some potential pathways such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,which may be important in the progression of JIA were screened.Conclusions The pathogenesis of JIA,as well as its potential causal genes,can be captured through bioinformatics methods,so it may be used as time and cost saving method in experimental study and clinical application.
