The biological behavior and significance of aging bone mesenchymal stem cells
10.3760/cma.j.issn.1673-4181.2015.01.015
- VernacularTitle:衰老的骨髓间充质干细胞生物学行为及其意义
- Author:
Jing ZHANG
;
Xiaoge XU
;
Junfang TENG
;
Yanjie JIA
- Publication Type:Journal Article
- Keywords:
Bone mesenchymal stem cells;
microRNAs;
Biological behaviour
- From:
International Journal of Biomedical Engineering
2015;38(1):-
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow mesenchymal stem cells (BMSCs),which can be isolated from organs and tissues,are cell populations with high degree of plasticity,similar to hematopoietic stem cells in bone marrow,and can be in vitro cultured,induced and amplified.BMSCs are increasingly used in gene therapy,cell therapy and tissue engineering.BMSCs have been currently studied in a number of autologous transplantations,while not all BMSCs are suitable for autologous transplantation.BMSCs exhibit biological aging gradually when cultured in vitro.Biological aging can be divided into age-induced senescence and long-term passage induced senescence.Aging BMSCs demonstrate changes in biological behaviour which reduces the success rate of autologous transplantation.In this review,biological aging BMSCs are discussed in order to provide help for the transplantation of BMSCs.
