Experimental study on the treatment of allergic rhinitis with photodynamic therapy
10.3760/cma.j.issn.1673-4181.2014.05.009
- VernacularTitle:光动力疗法治疗变应性鼻炎的实验性研究
- Author:
Shanshan WANG
;
Yongwang HUANG
;
Huijuan YIN
;
Yingxin LI
;
Xiaowei GAO
;
Jie OUYANG
- Publication Type:Journal Article
- Keywords:
Photodynamic therapy;
Allergic rhinitis;
Nasal mucosa;
Light microscope;
Transmission electron microscope
- From:
International Journal of Biomedical Engineering
2014;37(5):291-294,后插4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily investigate the therapeutic effect of photodynamic therapy (PT) treating allergic rhinitis (AR).Methods Eighteen New Zealand rabbits were randomly divided into 3 groups,experimental group A,negative control group B and blank control group C.Rabbits of A and B groups were sensitized with ovalbumin (OVA) to get animal AR model.Group A was treated with PDT while group B and C were applied with natural light treatment.Symptoms and signs before and after treatment were compared and the change of nasal mucosa was observed with light microscope and transmission electron microscope.Results After PDT treatment,group A rabbits' AR symptoms and signs were improved significantly compared to group B,light microscope and transmission electron microscope observation showed that the number of inflammatory cells of group A rabbits decreased significantly and the mucosal structure returned to normal after PDT treatment.After 21 d,as compared with group C,the differences of the times of sneezing and scratching and nasal secretion had no statistical significance (P＞0.05).Conclusions PDT has certain therapeutic effect in experimental AR treatment,which can be used in AR treatment after consummating its therapeutic mechanism.
