Pathologic changes of lymph nodes, liver and bone marrow in adult-onset Still's disease: a report of 3 cases
10.3760/cma.j.issn.1006-9801.2015.05.009
- VernacularTitle:成年人Still病三例淋巴结、骨髓和肝脏病理学特征分析
- Author:
Yunxin ZHANG
;
Meiqiong CHEN
;
Jinping ZHANG
;
Rongshan ZHANG
- Publication Type:Journal Article
- Keywords:
Still's disease;
Adult-onset;
Lymph nodes;
Liver;
Bone marrow;
Pathologic diagnosis
- From:
Cancer Research and Clinic
2015;27(5):332-335,349
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathological characteristics of lymph nodes,liver and bone morrow in adult-onset still' s disease (AOSD).Methods The clinical data of three AOSD patients were collected and their biopsy of enlarged lymph nodes,liver and bone marrow were analyzed by histology and immunohistochemistry.Results In AOSD lymphadenopathy,there were high lymph node hyperplasia,partial architecture damage and an intense paracortical hyperplasia along with diffused infiltration of large immunoblasts,activated lymphocytes,Langerhans cells,histocytes,neutrophils and chronic inflammatory cells.Bone marrow biopsy showed a significant increase in the proportion of granulocytes and erythrocytes,with apparently increased segmented neutrophils.Hepatic biopsy showed hepatocellular spotty necrosis.Meanwhile,there was some infiltration of lymphocytes and neutrophils in the periportal fibrosis area.Immunohistochemical staining showed CD21 expression in lymphoid follicle remnants and B cell markers with few T markers in most of immunoblasts.Conclusion The pathological characterizations of lymph nodes,liver and bone marrow provide important clues to the diagnosis of AOSD as well as its differential diagnosis.
