The effect of diltiazern on patency rate of arteriovenous anastomosis in rat and how it works
10.3760/cma.j.issn.1001-4497.2014.10.014
- VernacularTitle:地尔硫卓对大鼠动静脉吻合术后血管通畅率的影响
- Author:
Qiang GAO
;
Changjiang YU
;
Zewei ZHANG
- Publication Type:Journal Article
- Keywords:
Arteriovenous anastomosis;
Diltiazem;
Thromboxane B2
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2014;30(10):622-623,631
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was designed to study the effect of Diltiazem on patency rate of arteriovenous anastomosis in rat and how it works.Methods 24 SD rats were divided into control group and experimental group,12 rats in each group.Experimental group rats were gavaged with Diltiazem after vascular anastomosis.Control group rats were gavaged with water.By comparing the patency rate and the thickness of artery to make sure whether Diltiazem will affect the patency rate.;By comparing the clotting time,prothrombin time,artial thromboplastin time,and serum thromboxane B2 levels to explore the pathway of diltiazem.Results The patency rate was 75％ in the experimental group and 25％ in control group.Compared with the control group,experimental group venous blood vessels in the film segment was significantly thicker,clotting time was prolonged,TXB2 levels in blood was decreased,the differences were statistically significant(P ＜ 0.05).There were no significant difference in prothrombin time and partial thromboplastin between two groups (P ＞ 0.05).Conclusion Diltiazem can inhibit the secretion of TXB2,antagonize the effct of antiplatelet,and increase the patency rate of vascular anastomosis in rats.
