Expression of Topo Ⅱ in osteosarcoma after chemotherapy and its significance
10.3760/cma.j.issn.1006-9801.2014.10.012
- VernacularTitle:拓扑异构酶Ⅱ在化疗后患者骨肉瘤组织中的表达及其意义
- Author:
Jianghua WEI
;
Huixia ZHENG
;
Huanyu QI
;
Zhizhong LIANG
;
Junwei ZHANG
- Publication Type:Journal Article
- Keywords:
Osteosarcoma;
DNA topoisomerases,type Ⅱ;
Neoplasm metastasis;
Drug resistance,neoplasm;
Prognosis
- From:
Cancer Research and Clinic
2014;26(10):689-690,694
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe into the content of DNA Topo Ⅱ in osteosarcoma after chemotherapy.Methods 30 patients with osteosarcoma received two courses of chemotherapy treatment before the surgical resection of the tumor tissue.Then immunohistochemistry was used to detect the content of Topo Ⅱ in tissues and detected its relationship in pathology.Results There were 8 out of 30 cases in which Topo Ⅱ was presented positive in osteosarcoma (26.7 %).The protein content of Topo Ⅱ was unrelated to the patient' s age,gender,degree of tumor malignancy,tumor location and translocation or Enneking staging (P > 0.05),but related to patients survival rate (P < 0.05).Conclusion Patients with lower expression of Topo Ⅱ are more likely to have poor prognosis.