Expression of Topo Ⅱ in osteosarcoma after chemotherapy and its significance

VernacularTitle:拓扑异构酶Ⅱ在化疗后患者骨肉瘤组织中的表达及其意义
Author: Jianghua WEI ; Huixia ZHENG ; Huanyu QI ; Zhizhong LIANG ; Junwei ZHANG
Publication Type:Journal Article
Keywords: Osteosarcoma; DNA topoisomerases,type Ⅱ; Neoplasm metastasis; Drug resistance,neoplasm; Prognosis
From: Cancer Research and Clinic 2014;26(10):689-690,694
CountryChina
Language:Chinese
Abstract: Objective To probe into the content of DNA Topo Ⅱ in osteosarcoma after chemotherapy.Methods 30 patients with osteosarcoma received two courses of chemotherapy treatment before the surgical resection of the tumor tissue.Then immunohistochemistry was used to detect the content of Topo Ⅱ in tissues and detected its relationship in pathology.Results There were 8 out of 30 cases in which Topo Ⅱ was presented positive in osteosarcoma (26.7 ％).The protein content of Topo Ⅱ was unrelated to the patient' s age,gender,degree of tumor malignancy,tumor location and translocation or Enneking staging (P ＞ 0.05),but related to patients survival rate (P ＜ 0.05).Conclusion Patients with lower expression of Topo Ⅱ are more likely to have poor prognosis.