Expression of 14-3-3ε in bladder urothelial carcinoma and its correlation with clinicopathologic features
10.3760/cma.j.issn.1006-9801.2014.10.006
- VernacularTitle:14-3-3ε在膀胱尿路上皮癌中的表达及其临床病理意义
- Author:
Yuanyuan ZHAO
;
Yanfeng XI
;
Xuanqin YANG
;
Shuxiong TIAN
;
Nan LYU
;
Yu CUI
- Publication Type:Journal Article
- Keywords:
14-3-3ε protein;
Bladder urothelial carcinoma;
Biological markers
- From:
Cancer Research and Clinic
2014;26(10):670-672,676
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of 14-3-3ε protein in the bladder urothelial carcinoma (BUC) and to explore its association with the clinicopathologic features.Methods The bladder urothelial carcinoma samples were divided into three groups:normal control group of 10 cases,low-grade malignant BUC group of 25cases (includes 5 cases of papilloma,10 cases of PUNLMP and 10 cases of low grade non-invasive papillary urothelial carcinoma),high-grade malignant BUC group of 21 cases (includes 11 cases of high-grade non invasive papillary urothelial carcinoma and 10cases of infiltrating carcinoma).The expression and location of 14-3-3ε in three groups were detected by immunohistochemical EnVision and the relationship with clinicopathologic parameters was analyzed.Results 14-3-3ε expression was observed in the cytoplasm of the cell.The expression of 14-3-3ε in normal control group was 90 ％ (9/10),low-grade malignant BUC group was 72.0 ％ (18/25),high grade malignant BUC group was 14.3 ％ (3/21).It correlated with histological grading but had not showed correlation with other clinicopathologic parameters.There was significant difference in 14-3-3ε expression between the high grade malignant BUC group and the low-grade malignant BUC group,the high grade malignant BUC group and norml control group (all P ＜ 0.05).Conclusions 14-3-3ε plays an important role in carcinogenesis of BUC.It may be a biomarker for early diagnosis and classification of BUC and shows promise for clinic application.
