Aspirin Improves Survival of Colorectal Cancer Patients:A Meta-analysis and Systematic Evaluation
- VernacularTitle:服用阿司匹林对结直肠癌患者生存获益的Meta分析与系统评价
- Author:
Peng MIAO
;
Lin GUAN
;
Chengzhong XING
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
aspirin;
prognosis;
meta-analysis
- From:
Journal of China Medical University
2015;(6):528-532,537
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically assess the relationship between oral administration of aspirin and survival benefit for patients with colorec?tal cancer(CRC)by meta?analysis. Methods Relevant studies were identified through searching PubMed and EMBASE. Random?effects model was derived to composite the pooled hazard ratio for overall mortality and CRC?specific mortality. The subgroup analysis was conducted for included data,and the bias analysis was reported. Results Thirteen studies on aspirin therapy were finally included in this meta?analysis. The overall surviv?al benefit associated with oral administration of aspirin represented an HR of 0.83(95%CI:0.71?0.96). Oral administration of aspirin was also asso?ciated with CRC?specific survival(HR=0.77,95%CI:0.64?0.93). No evidence was observed of an association between prediagnostic aspirin use and CRC overall survival(HR=1.00,95%CI:0.85?1.18)or CRC?specific survival(HR=0.97,95%CI:0.83?1.13). Conclusion These findings provide further indication that post?diagnostic aspirin therapy can improve CRC prognosis.
