Causes of false-positive anti-HCV in non-syndromic cleft lip and palate with serum chemiluminescence test
10.3969/j.issn.1000-484X.2015.06.016
- VernacularTitle:非综合征型唇腭裂患儿血清抗-HCV 化学发光法出现假阳性的原因分析
- Author:
Juying WANG
;
Feng LI
;
Lirong ZHOU
;
Xiuying TANG
;
Li LI
- Publication Type:Journal Article
- Keywords:
Non-syndromic cleft lip and palates;
CLIA;
Weakly reactive;
False positive;
Tracking monitor
- From:
Chinese Journal of Immunology
2015;(6):795-797,802
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the causes of false-positive anti-HCV in non-syndromic cleft lip and palate with serum chemiluminescence test. Methods:We performed a hospital-based,case-control study of 4 050 patients with non-syndromic cleft lip and palate and 8 547 control patients without cleft lip and palate to evaluate associations between positive anti-HCV and non-syndromic cleft lip and palate. CLIA test were used for detect anti-HCV in control group. RIBA and FQ-PCR were used for confirming the result of the positive samples of CLIA test. CLIA test were used for detect anti-HCV in case group until CLIA test was negative. IgG,RF and ANA were used for case-control comparisons. Results:The detection rate of anti-HCV were higher in the case group than that of control group (P<0. 05). The false-positive rate was 1 percent based on testing of 4 050 patients. These samples were negative after opration 1-19 months. There were no change among IgG, RF and ANA in the false-positivepatients. Conclusion: False-positive anti-HCV in non-syndromic cleft lip was possible associated with abnormal plasma metabolic product. It can be excluded by track monitoring.
