Analysis of correlation of AMH expression and insulin resistance degree in PCOS rats
10.3969/j.issn.1000-484X.2015.06.026
- VernacularTitle:多囊卵巢综合征大鼠AMH 表达与胰岛素抵抗的相关性研究
- Author:
Xiaohong LI
;
Hong YAN
;
Taifang WEN
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Anti-Mullerian hormone;
Insulin;
Insulin Receptor;
Insulin Resistance
- From:
Chinese Journal of Immunology
2015;(6):835-837,839
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the correlation between the expression of anti-mullerian hormone( AMH) and insulin resistance (IR)degree in serum and local ovary and single follicle induced by polycystic ovary syndrome(PCOS)model. Methods: PCOS rat model was constructed by DHEA method. and then calculate the homeostasis model assessment of insulin resistance( HOMA-IR) val-ues. according to HOMA-IR value ,the object is simple screening PCOS group,PCOS merger IR group and control group were detected by immunohistochemistry model mice, the expression of AMH and insulin receptor in serum and single follicle and ovary were checked. Results:The serum FINS level and HOMA-IR was significantly higher in PCOS with IR group compared with that in control group and PCOS without IR group(P<0. 05);while the combined IR PCOS group T,Flns and HOMA-IR was significantly higher in the control group(P <0. 05);Pearson correlation analysis showed that local ovarian AMH expression of insulin receptor expression was no significant correlation(r=0. 015,P>0. 05);ovary AMH expression and serum insulin significantly was correlated(r=0. 671,P=0. 003),a single follicle AMH expression of insulin receptor expression was no significant correlation(r=0. 011,P>0. 05);HOMA-IR and serum AMH had significant positive correlation(r=0. 683,P=0. 001). Conclusion: AMH were positively correlated with serum insulin levels in PCOS rat. The expression of AMH in partial ovarian was positively correlated with the insulin receptor, while the expression of AMH in single follicle was no significant correlation with the insulin receptor. Howerer,whether the expression of AMH is correlation with hyperandrogenism has need further study.
