Correlation and dynamic observation of ambulatory arterial stiffness index and target organ damage of hypertension
10.3969/j.issn.1671-8348.2015.14.009
- VernacularTitle:动态动脉硬化指数与高血压靶器官损伤的相关性及动态观察
- Author:
Jinquan GAO
;
Junfeng LI
;
Anwei WANG
- Publication Type:Journal Article
- Keywords:
hypertension;
ambulatory arterial stiffness index;
carotid intima-media thickness;
urinary microalbumin;
renal vascular resistant indices
- From:
Chongqing Medicine
2015;(14):1897-1899,1901
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of ambulatory arterial stiffness index (AASI) and target organ damage (TODs) after antihypertensive treatment in hypertensive patients .Methods A total of 300 cases of newly diagnosed hypertension were screened out and after strictly controlling blood pressure ,completed the ambulatory blood pressure and target organ damage inspection by 1‐year follow‐up .The dynamic changes of AASI and target organ damage were observed .Results After 1‐year anti‐hypertensive therapy ,AASI showed the gradually descending trend ,compared with before treatment ,began to decline at 6 months , decreased significantly after 1 year ;AASI showed the independent positive correlation with the intima‐media thickness(IMT) of ca‐rotid artery ,urine microalbumin(UMA) ,renal vascular resistance index(RRI) and left ventricular mass index(LVMI) ,and inde‐pendent negative correlation with endogenous creatinine clearance rate(Ccr) before and after treatment ;the multiple linear regres‐sion analysis showed that IMT ,UMA ,RRI ,Ccr and LVMI had significant correlation with AASI .After 1 year of therapy ,IMT , UMA ,RRI ,Ccr ,LVMI had shown some improvement(P<0 .05) .Conclusion AASI can be used as an indicator for evaluating arte‐riosclerosis and predicting the target organ damage in hypertension .
