Differential diagnosis value of pro-GRP and NSE in small cell lung cancer
10.3969/j.issn.1673-4130.2015.12.003
- VernacularTitle:血清标志物pro-GRP、NSE在小细胞肺癌鉴别诊断中的价值
- Author:
Yachao YAO
;
Lei LI
;
Houkuang QIU
;
Xiaoyun WU
;
Fang YAN
;
Zhen ZHANG
;
Yahong LI
;
Nan LI
;
Zeyong LI
;
Zhi ZHANG
- Publication Type:Journal Article
- Keywords:
small cell lung cancer;
non-small cell lung cancer;
differential diagnosis
- From:
International Journal of Laboratory Medicine
2015;(12):1647-1648,1650
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the values of gastrin‐releasing peptide (pro‐GRP) and neuronspecific enolase (NSE) in differ‐ential diagnosing of small cell lung cancer (SCLC) .Methods Serum samples from 120 SCLC patients ,130 non‐small cell lung canc‐er (NSCLC) ,80 Patients with benign lung disease and 90 healthy donors were collected to detect the level of pro‐GRP and NSE .All data were analyzed by SPSS13 .0 and then we analyzed the serum level and positive rates of the two tumor markers .ROC was gener‐ated by GraphPad Prism 5 .Results The expression level of pro‐GRP and NSE in SCLC group were significant higher than NSCLC group、benign lung disease group and healthy donors group (P<0 .05) .The positive rates of pro‐GRP in SCLC were higher than the other three groups (P<0 .05) .However ,there had no significant difference between SCLC group and NSCLC group in the posi‐tive rates of NSE(P>0 .05) .ROC area under curve of pro‐GRP ,NSE and both were 0 .890 ,0 .810 and 0 .915 ,separately .Conclusion The tumor biomarker of NSE could only identify of benign and malignant lung diseases ,but can not identify the type of lung canc‐er including SCLC and NSCLC ;Nonetheless the tumor biomarker of pro‐GRP could not only identify benign and malignant lung dis‐eases ,but also identify the pathological type of SCLC and NSCLC ;Combined determination of pro‐GRP and NSE had significant values for the differential diagnosis of SCLC .
