Determination of Trace Nickel in Agomelatine by Inductive Coupled Plasma Atomic Emission Spectrometry
- VernacularTitle:电感耦合等离子体原子发射光谱法测定阿戈美拉汀中的微量镍
- Author:
Haixia YANG
;
Yanxin LIU
;
Fengchao LI
;
Yuren XING
- Publication Type:Journal Article
- Keywords:
Inductive coupled plasma atomic emission spectrometry;
Agomelatine;
Nicke
- From:
China Pharmacist
2015;(6):1030-1031,1032
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method for the determination of trace nickel in agomelatine. Methods:An inductive coupled plasma atomic emission spectrometry method was applied in the determination at 221. 648 nm. The sample solution was prepared by the ignited residue of agomelatine. The content of nickel was determined using the standard curve. Results:The linear range was 0. 025-1. 000 μg·ml-1(r=0. 999 8). The RSD of precision was 0. 63%. The detection limit was 0. 000 8μg·ml-1. The quantitative limit was 0. 003μg·ml-1 . The average recovery was 99. 4% with RSD of 2. 20%. The RSD of repeatability was 1. 33%. Conclusion:The method is simple, sensitive and accurate in the determination of trace nickel in agomelatine.
