Correlation Between Diffusion Weighted Imaging Parameters and Protein Content in Fluid:An Experimental Study
10.3969/j.issn.1005-5185.2015.06.004
- VernacularTitle:扩散加权成像信号与液体内蛋白质的相关性实验研究
- Author:
Kun LI
;
Wei LI
;
Zhenyu PAN
;
Huiming YI
;
Yingmin CHEN
- Publication Type:Journal Article
- Keywords:
Protein;
Magnetic resonance imaging;
Diffusion weighted imaging;
Apparent diffusion coefficient;
In vitro
- From:
Chinese Journal of Medical Imaging
2015;(6):413-417,422
- CountryChina
- Language:Chinese
-
Abstract:
Purpose Protein is the main influencing factors for diffusion weighted imaging (DWI) signals and apparent diffusion coefficient (ADC), it results in hyperintensity on DWI and low ADC, but not fully matched in clinic. This paper aims to investigate the effect of protein type and concentration on the signal intensity (SI) and ADC of DWI. Materials and Methods Different concentrations of albumin, globulin solution and the mixed solution were created in vitro. DWI was performed on GE 1.5T superconducting nuclear MRI system. Results ① There was a linear negative correlation between the ADC value and the concentrations of protein solution (at 37℃, ra= - 0.849, Pa<0.05; rg= - 0.843, Pg<0.05; at 40℃, ra= - 0.894, Pa<0.05; rg= - 0.819, Pg<0.05);there was a linear positive correlation between the SI of DWI and the concentrations of the albumin solution (at 37℃, r=0.753, P<0.05; at 40℃, r=0.845, P<0.05). There was no correlation between the SI of DWI and the concentrations of the globulin solution (at 37℃, r= - 0.222, P>0.05; at 40℃ , r= - 0.270, P>0.05). ② SI of the albumin solution was significantly higher than the globulin solution at the same concentration and temperature (t=3.96, P<0.001); the ADC values were not statistically different between the albumin and the globulin solution (t=0.61, P>0.05). Conclusion The nature of the cystic fluid can be understood preliminarily through quantitative analysis of the cystic fluid DWI and ADC values, so as to provide theoretical basis for the qualitative diagnosis of cystic lesions in vivo.
