Effects of Telmisartan and Valsartan on Insulin Resistance in Obese Hypertensive Patients
10.3870/yydb.2015.06.018
- VernacularTitle:替米沙坦和缬沙坦对肥胖高血压患者胰岛素抵抗的影响
- Author:
Xinying WU
;
Jingjing LI
;
Hongping SONG
;
Yong HAN
- Publication Type:Journal Article
- Keywords:
Telmisartan;
Valsartan;
Hypertension;
Obese;
Insulin resistance
- From:
Herald of Medicine
2015;(6):765-767,768
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of telmisartan and valsartan on insulin resistance in obese hypertensive patients. Methods Sixty-eight patients with essential hypertension and body mass index ( BMI) ≥25 kg · ( m2 ) -1 were randomly divided into the telmisartan group (33 cases) and valsartan group (35 cases). Blood pressure, fasting serum glucose, fasting insulin (Fins) and insulin resistance (HOMA-IR) were measured before and after 16 weeks treatment. Results Compared with basal levels, SBP and DBP were significantly decreased in both group ( P<0. 01). Fins and HOMA-IR were significantly decreased in telmisartan group [(12. 9±2. 9) mU·L-1 vs. (10. 9±2. 2) mU·L-1 (P<0. 01); (3. 1±0. 7) vs. (2. 7±0. 6) (P<0. 01), respectively], while no such changes were found in valsartan group [(12. 9 ±3. 0) mU·L-1 vs. (12. 7±2. 7) mU·L-1 ( P > 0. 05);( 3. 0 ± 0. 7) vs. (3. 0 ± 0. 7) ( P > 0. 05), respectively]. Conclusion In obese hypertensive patients, telmisartan and valsartan exert similar antihypertensive effect, but telmisartan may have a benefit in insulin resistance in comparison to valsartan.
