Expression of IGF-Ⅱ and IGFbP-6 in colorectal cancer and their significance
10.13315/j.cnki.cjcep.2015.06.007
- VernacularTitle:结直肠癌中IGF-Ⅱ、IGFBP-6的表达及意义
- Author:
Jing XUE
;
Yang ZHAO
;
Jianwei ZHANG
;
Yan JIAO
;
Xingbin SHEN
- Publication Type:Journal Article
- Keywords:
co1orecta1 neop1asms;
insu1in-1ike growth factor-Ⅱ;
insu1in-1ike growth factor binding protein-6;
immunohistochemistry;
RT-PCR
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(6):628-631,632
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of IGF-Ⅱand IGFBP-6 in co1orecta1 cancer,and to exp1ore the c1inica1 significance in co1orecta1 cancer. Methods IGF-Ⅱand IGFBP-6 were detected by immunohistochemistry and RT-PCR in 50 cases of co1orecta1 cancer(experimenta1 group)and 50 cases of the adjacent mucosa(contro1 group). Results (1)In the experimenta1 group,the ex-pression 1eve1 of IGF-Ⅱprotein and mRNA was significant1y higher than the contro1 group. The expression 1eve1s of IGF-Ⅱprotein and mRNA in co1orecta1 cancer were significant1y 1ower than the contro1 group.(2)The expression 1eve1s of IGF-Ⅱand IGFBP-6 were sig-nificant1y different between different tumor infi1tration depth,1ymph node metastasis,invasion depth and Duke’s stages( P<0. 05), but no difference between genders,age and the degree of tumor differentiation( P>0. 05). Conclusions There is a obvious corre1a-tion between of IGF-Ⅱ and IGFBP-6 in c1inica1 patho1ogica1 parameters in co1orecta1 cancer. Combined detection of the two markers may be the bio1ogica1 indicators of occurrence and prognosis of co1orecta1 cancer,and provide a new scheme for diagnosis and treatment of co1orecta1 cancer.
