HLA and Disease Associations in Koreans.
- Author:
Stephen AHN
1
;
Hee Back CHOI
;
Tai Gyu KIM
Author Information
- Publication Type:Review
- Keywords: HLA; Disease association; Korean
- MeSH: Alleles; Autoimmune Diseases; Chromosomes, Human, Pair 6; Clinical Coding; Communicable Diseases; Disease Susceptibility; Genetic Variation; Histocompatibility Testing; Humans; Immune System; Leukocytes; Major Histocompatibility Complex; Proteins; Transplants
- From:Immune Network 2011;11(6):324-335
- CountryRepublic of Korea
- Language:English
- Abstract: The human leukocyte antigen (HLA), the major histocompatibility complex (MHC) in humans has been known to reside on chromosome 6 and encodes cell-surface antigen-presenting proteins and many other proteins related to immune system function. The HLA is highly polymorphic and the most genetically variable coding loci in humans. In addition to a critical role in transplantation medicine, HLA and disease associations have been widely studied across the populations world-wide and are found to be important in prediction of disease susceptibility, resistance and of evolutionary maintenance of genetic diversity. Because recently developed molecular based HLA typing has several advantages like improved specimen stability and increased resolution of HLA types, the association between HLA alleles and a given disease could be more accurately quantified. Here, in this review, we have collected HLA association data on some autoimmune diseases, infectious diseases, cancers, drug responsiveness and other diseases with unknown etiology in Koreans and attempt to summarize some remarkable HLA alleles related with specific diseases.
