Evaluation of the hypoglycemic effect of the ethanol extracts of plantago asiatica in different hyperglycemic animal models
10.3760/cma.j.issn.1008-6706.2015.12.019
- VernacularTitle:车前子醇提取物对不同糖尿病模型小鼠降血糖效果的评价
- Author:
Juwei ZHANG
;
Jianshun ZHANG
;
Haiying ZHANG
- Publication Type:Journal Article
- Keywords:
Hyperglycemi;
Plantago asiatica ethanol extracts;
Mice
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(12):1817-1819,1820
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the hypoglycemic effects of the ethanol extracts of Plantago asiatica in different diabetes animal models.Methods The different diabetes animal models (adrenaline -induced hyperglyce-mic models,glucose -induced hyperglycemic models,alloxan -induced hyperglycemic models)have been applied. Results Compared with model groups,the ethanol extracts of Plantago asiatica at high dose[(10.26 ±1.76)mmol/L] possessed obviously hypoglycemic effects on adrenaline -induced hyperglycemic mice[(14.74 ±2.47)mmol/L](t =2.558,P <0.01)and the middle dose[(11.74 ±2.35)mmol/L]possessed hypoglycemic effects on adrenaline -induced hyperglycemic mice[(14.74 ±2.47)mmol/L](t =1.524,P <0.05 );Compared with model groups,the ethanol extracts of Plantago asiatica at high dose[(11.38 ±1.76)mmol/L]possessed obviously hypoglycemic effects on glucose -induced hyperglycemic mice[(16.15 ±2.49)mmol/L](t =2.710,P <0.01 )and the middle dose [(13.01 ±3.23)mmol/L]possessed hypoglycemic effects on glucose -induced hyperglycemic mice(t =1.334,P <0.05);In addition,the ethanol extracts of Plantago asiatica could significantly inhibit the rise of blood glucose level and had certain hypoglycemic effect on halloxan -induced diabetic mice.Conclusion The ethanol extracts of Planta-go asiatica have a significant role in lowering blood glucose at a certain extent.
