Effect of diosmin on immune mediated factors in serum and prostatic fluid and clinical effect in patients with chronic prostatitis
- VernacularTitle:地奥斯明对老年慢性前列腺炎患者血清及前列腺液内免疫介导因子的影响及临床疗效研究
- Author:
Min LIU
;
Tongyu ZHU
;
Wei YAN
;
Huifeng LI
- Publication Type:Journal Article
- Keywords:
chronic prostatitis;
MIP-1α;
MIP-2;
diosmin
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):121-123,126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore effect of diosmin on serum and prostatic fluid immune mediated factors and clinical effect in patients with chronic prostatitis.Methods 89 cases of old male patients with chronic non bacterial prostatitis were selected, and divided into two groups.The control group were treated with universal tablets, the experiment group were treated on the base of the control group with diosmin.12 weeks as a course.Clinic effect, adverse reaction rate, prostatic fluid MIP-2 and MIP-1αwere compared after treatment.Results Compared with control group, MIP-1αand MIP-2 in serum and prostatic fluid were lower(P<0.05),NIH-CPSI score and QOL scores were lower(P<0.05), total effective rate was higher than control group(P<0.05),the incidence of adverse reactions was lower(P<0.05).Conclusion Diosmin can reduce MIP-1α, MIP-2 in serum and prostate fluid of patients with chronic none bacterial prostatitis, and improve the pelvic pain, dysuria, sexual dysfunction and other symptoms, and has less adverse reaction.
