Effect of adrenocortical hormone on detection of NMO-IgG in neuromyelitisoptica patients
- VernacularTitle:肾上腺皮质激素对脊髓炎患者血清NMO-IgG抗体检测的影响
- Author:
Wenyong GAO
- Publication Type:Journal Article
- Keywords:
adrenocortical hormone;
neuromyelitis optica;
NMO-IgG;
aquaporin-4
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):130-132,136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of adrenocortical hormone on detection of NMO-IgG in neuromyelitis optica ( NMO ) patients.Methods 30 cases with NMO collected in the hospital according to the figures were randomly divided into adrenocorticotropic hormone group and control group, 15 cases in each group.adrenocorticotropic hormone group were given glucocorticoid therapy on the basis of conventional therapy.The control group were treated with conventional therapy, and The serum NMO-IgG levels were detected by indirect immunofluorescence taking stable expression of human origin aquaporin -4 (AQP4) in human embryonic kidney 293 (HEK293) cell line as substrate.Results 19 cases (63.3%) serum NMO-IgG positive patients in 30 cases with spinal cord inflammation, serum antibody titers from 1:115 to 1砄6355.The positive rate of serum NMO-IgG in adrenocorticotropic hormone group was 86.7%, which was higher than 40.0% in control group (χ2 =7.03,P<0.05).Conclusion The adrenocortical hormone could help the detection of NMO-IgG antibody and increase the efficiency of clinical diagnosis.
