Research progress on Nisin biosynthesis and breeding of high-yield strains
- VernacularTitle:乳链菌肽生物合成及高产菌株选育的研究进展
- Author:
Zhijian NI
;
Shaohua WANG
;
Fei LIU
;
Xiqiang ZHU
- Publication Type:Journal Article
- Keywords:
Nisin;
biosynthesis;
key genes;
regulation;
high-yield strains
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):171-175,180
- CountryChina
- Language:Chinese
-
Abstract:
Nisin, produced by several strains in the growth process of Lactococcus lactis, is a natural antimicrobial polypeptide.Now, Nisin has served as an effective and safe food additive extensively used in food industry in many countries and regions because of its excellent antimicrobial activity.However, the current production of Nisin is largely fermented by lactobacillus and its industrialized production still can not meet enormous market needs, therefore establishing reasonably high-yield Nisin strains is of great significance.This review mainly summarizes the development pathway of molecule based on the functional expression of Nisin biosynthetic genes and regulation of gene expression, and also the study status on high Nisin-producing strains which provides practical foundation for further study on expected strains as well as some useful guidance for large-scale industrialized production of Nisin.
