Distribution characteristics and dynamic observation of antimicrobial re-sistant spectrum of carbapenem-resistant Acinetobacter baumannii
10.3969/j.issn.1671-9638.2015.05.006
- VernacularTitle:耐碳青霉烯类鲍曼不动杆菌临床分布及耐药谱动态观察
- Author:
Qunli BAO
;
Hongliang WANG
;
Jun KE
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
carbapenemase;
carbapenem-resistant antibiotic;
carbapenem-resistant Acinetobacter baumannii;
drug resistance,microbial;
healthcare-associated infection
- From:
Chinese Journal of Infection Control
2015;(5):311-313,316
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution characteristics and antimicrobial resistance of carbapenem-resistantAcinetobacter baumannii (CRAB),and to guide effective clinical prevention and rational antimicrobial use. Methods Data about clinically isolated CRAB between January 2009 and December 2013 were analyzed retrospec-tively,distribution and antimicrobial resistance were analyzed by WHONET 5.5 software.Results A total of 888 Acinetobacter baumannii strains were isolated,421 of which were CRAB,the isolation rate was 47.4%,the isola-tion rates in 2011 ,2012 and 2013 were all about 50.0%;CRAB strains were mainly isolated from sputum (73.4%) and mostly distributed in intensive care unit (ICU)(61 .3%),followed by neurosurgery department (12.4% ). CRAB presented highly antimicrobial resistance.Except cefotaxime and cefatriaxone,resistant rates of CRAB to the other detected antimicrobial agents(ceftazidime,cefepime,cefoperazone/sulbactam,aztreonam,imipenem,amika-cin,gentamycin,minocycline,chloramphenicol,levofloxacin,ciprofloxacin,and compound sulfamethoxazole)were all higher than non-CRAB isolates(all P ≤0.01),Compared with non-CRAB isolates,The resistant rate of CRAB to cefoperazone/sulbactam was the lowest(<15%),followed by minocycline,resistant rates to other antimicrobial agents were all >80.0%.Conclusion Surveillance of CRAB should be further strengthened.It is necessary to fo-cus on the control and prevention of healthcare-associated infection in ICU patients and respiratory system.
