MDSCs are upregulated in PSGL-1-deficient mice
10.3969/j.issn.1671.7856.2015.006.009
- VernacularTitle:PSGL-1缺失导致 MDSCs 上调
- Author:
Zeqi ZHOU
;
Jiangchao LI
;
Xiaohan ZHANG
;
Lu HAN
;
Yuxiang YE
;
Lijing WANG
- Publication Type:Journal Article
- Keywords:
P-selectin glycoprotein ligand 1,PSGL-1;
Myeloid-derived suppressor cells,MDSCs;
Spleen;
Bone marrow;
Transgenic mice;
PSGL-1-deficient mice
- From:
Chinese Journal of Comparative Medicine
2015;(6):42-44,45
- CountryChina
- Language:Chinese
-
Abstract:
Objective PSGL-1 is specifically expressed in leucocytes.The aim of this study was to explore the changes of myeloid-derived suppressor cells (MDSCs) in the spleen and bone marrow in PSGL-1-deficient mice.Methods PSGL-1 -/-mice were used in the experiment.After identification of the offsprings, flow cytometry was used to test the expression of CD11b and Gr-1 in C57 and PSGL-1 -/-mice.Results Compared with the C57 mice, the expression of MDSCs was up-regulated in the PSGL-1-deficient mice ( P <0.001).Conclusion The expression of MDSCs is upregulated in PSGl-1-deficient mice.
