The significance of combined detection of PTX3 and NT -ProBNP in evaluating of the prognosis of the patients with AMI combined T2DM
10.3760/cma.j.issn.1008-6706.2015.13.019
- VernacularTitle:长正五聚蛋白3、N 末端脑钠肽前体联合检测在急性心肌梗死并2型糖尿病患者预后判断中的意义
- Author:
Yanxia ZHU
;
Xinxin GONG
;
Xiaofang WANG
;
Qi ZANG
;
Wei ZHANG
;
Yuanyuan WANG
;
Qian LIU
- Publication Type:Journal Article
- Keywords:
Myocardial Infarction;
Diabetes Mellitus,Type 2;
Natriuretic Peptide,Brain;
Prognosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(13):1974-1976,1977
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of PTX3,NT -ProBNP level and the correlation between them and the prognosis of the patients with AMI combined T2DM.Methods 143 patients with primary AMI were enrolled,of which 63 patients with type 2 diabetes (observation group)and 80 patients with no diabetes (control group).Plasma PTX3 values were measured with ELISA method and NT -ProBNP was detected by the electrochemi luminescence method.All patients were observed for the occurrence of MACE during hospitalization and 12 months after discharge.The correlation between PTX3,NT -ProBNP concentration and occurrence of MACE in observation group were analyzed.Results The PTX3,NT -ProBNP concentration[(8.95 ±5.06)ng/mL,(1 609 ±1 049)pg/mL]in the observation group were significantly higher than those in the control group[(7.03 ±3.70)ng/mL,(1 198 ± 809)pg/mL](P =0.010,P =0.009);The number(n =26)of patients with occurrence of MACE in the observation group was significantly higher than 15 cases in the control group(P =0.003).In the observation group,the PTX3, NT -ProBNP concentration[(10.98 ±5.45)ng/mL,(2 007 ±1 097)ng/mL]in patients with MACE were signifi-cantly higher than those in patients without MACE[(7.53 ±4.28)ng/mL,(1330 ±930)ng/mL](P =0.007,P =0.010),and in MACE group,the PTX3,NT -ProBNP concentration[(13.88 ±6.84)ng/mL,(2 596 ±1 333)ng/mL] in patients with death weresignificantly higher than those in patients without death[(9.18 ±3.52)ng/mL,(1 639 ± 751)ng/mL](P =0.029,P =0.023).Conclusion More strong chronic inflammatory reaction and serious myocar-dial injury might occur in the patients with AMI combined and T2DM,and those patients would have poorer prognosis. The combined detection of PTX3,NT -ProBNP has an important significance in evaluating of the degree of myocardial damage and the prognosis of the patients with AMI combined T2DM.
