Changes and significance of neutrophil gelatinase -associated lipocalin and Ghrelin levels in peripheral blood of patients with acute pancreatitis
10.3760/cma.j.issn.1008-6706.2015.13.034
- VernacularTitle:急性胰腺炎患者外周血中性粒细胞明胶酶相关脂质运载蛋白和内源性脑肠肽水平变化及其意义
- Author:
Mei XUE
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Neutrophil gelatinase -associated lipocalin;
Ghrelin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(13):2019-2021,2022
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of neutrophil gelatinase -associated lipocalin (NGAL) and Ghrelin levels in peripheral blood of patients with acute pancreatitis and their significance.Methods 104 cases of acute pancreatitis were divided into mild acute pancreatitis group (n =65 )and severe acute pancreatitis group (n =39),according to the conditions of the patients.The clinical indexes of all subjects were collected.The levels of NGAL and Ghrelin in plasma were detected by enzyme -linked immunosorbent assay (ELISA method).Results The levels of NGAL and Ghrelin in severe acute pancreatitis group were (15.05 ±5.32)nmol/L and (349.7 ± 68.5)ng/L,respectively,which were higher than mild acute pancreatitis group,the differences were statistically signif-icant (t =10.239 and 14.453,P <0.05).Correlation analysis showed that the levels of NGAL in acute pancreatitis were positively correlated with white blood cell levels,C -reactive protein levels,APACHEⅡ score,BISAP index,CT-SI index and length of stay (r =0.447,0.335,0.626,0.534,0.497 and 0.372,all P <0.05),and the levels of Gh-relin in acute pancreatitis were positively correlated with white blood cell levels,C -reactive protein levels,APACHEⅡ score,BISAP index and CTSI index (r =0.392,0.407,0.592,0.481 and 0.506,all P <0.05 ).ROC curve showed that the levels of NGAL levels in the diagnosis of severe pancreatitis,the sensitivity was 79.5%,specificity was 93.8%,and area under the curve was 0.899 (95% CI:0.828 -0.970),plasma Ghrelin were 89.7%,90.8%, and 0.946 (95 % CI:0.897 -0.995),respectively.Conclusion The levels of NGAL and Ghrelin are significantly elevated in patients with severe acute pancreatitis,and they are positively correlated with the severity of patients'con-ditions.They have good diagnostic performance in early diagnosis of severe pancreatitis.
