The effect of general anesthesia combined with epidural anesthesia on postoperative cognitive function in elderly colon cancer patient underwent laparoscopic radical operation
10.3969/j.issn.1671-8348.2015.18.018
- VernacularTitle:硬膜外阻滞对老年全身麻醉下腹腔镜结肠癌根治术后认知功能的影响
- Author:
Yunchuan WANG
;
Jun WANG
- Publication Type:Journal Article
- Keywords:
anesthesia,epidural;
anesthesia,general;
cognition disorders;
elderly;
laparoscopic;
colonic neoplasms
- From:
Chongqing Medicine
2015;(18):2499-2500,2503
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of general anesthesia combined with epidural anesthesia on postoperative cogni‐tive dysfunction(POCD) in elderly colon cancer patient underwent laparoscopic radical operation .Methods 60 cases of elderly pa‐tients underwent laparoscopic radical colon cancer operation were sellected in Qionghai People′s Hospital of Hainan Province .The patients were divided into :general anesthesia control group(n=30)and general anesthesia combined with epidural anesthesia obser‐vation group (n=30) .The cognitive function was estimated by MMSE .The expression of S‐100βprotein was determined by ELISA analysis .Results The recovery time of respiratory depression ,drowsiness and extubation and remifentanil dosage was no no signifi‐cant differences between the two groups(P>0 .05) .The propofol dosage and rate of nausea and vomitting was lower in observation group than that in control group(P< 0 .05) .Before anesthesia ,the MMSE value was no significant difference between the two groups(P>0 .05) .MMSE value was decrease after operation for 1 and 3 d(P<0 .05) .However ,MMSE value was higher in obser‐vation group than that in control group (P<0 .05) .The rate of POCD in control group was 36 .7% and 23 .3% after operation for 1 and 3 d ,which was higher than that of 20 .0% and 13 .3% in observation group(P<0 .05) .Before anesthesia ,the S‐100βexpres‐sion was no significant difference between the two groups(P>0 .05) .The S‐100βexpression was increase after operation for 1 and 3 d(P<0 .05) .However ,the S‐100βexpression was lower in observation group than that in control group (P<0 .05) .Conclusion The general anesthesia combined with epidural anesthesia can decrease POCD in elderly colon cancer patient underwent laparoscopic radical operation ,with worthy of clinical application .
