Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing.
- Author:
Sunim PARK
1
;
Sun A IM
;
Ki Hyang KIM
;
Chong Kil LEE
Author Information
- Publication Type:Brief Communication
- Keywords: Hypocrellin A; MHC-restricted antigen presentation; Immunomodulator
- MeSH: Antigen Presentation; Cytosol; Dendritic Cells; Perylene; Quinones
- From:Immune Network 2011;11(6):412-415
- CountryRepublic of Korea
- Language:English
- Abstract: Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the H-2K(b)-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.
