Acute myeloid leukemia with t(16;21)(p11;q22):two cases report and literatures review

VernacularTitle:伴t(16;21)(p11;q22)急性髓系白血病二例并文献复习
Author: Zongchen ZHAO ; Zhifen ZHANG ; Yiqing LIU ; Ying JU ; Changzhi ZHANG ; Yong WANG ; Bingchang ZHANG
Publication Type:Journal Article
Keywords: Cytogenetics; Acute leukemia; Translocation
From: Journal of Leukemia & Lymphoma 2014;23(9):546-548,552
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical and laboratory characteristics of acute myeloid leukemia (AML) with t (16;21)(p11;q22) translocation.Methods Two patients diagnosed by morphology,cytochemical stain,immunology,cytogenetics and genetic testing.Similarities and differences of clinical characteristics and laboratory examination were analysed,along with a review of the literatures.Results According to the FAB classification,one patient was M4 and the other one was M1.The cytogenetic aberrations were 46,XY,t(16;21)(p11;q22)[16]/47,XY,t(16;21)(p11;q22),+21[4] of ease 1 and 46,XX,t(16;21)(p11;q22)[20] of case 2.Cytophagocytosis and CD56 antigen expression were found in both cases.The prognosis was poor in both cases.Conclusions AML with t(16;21)(p11;q22) is a specific type,which has unusual characteristics of morphology,immunology,cytogenetics,clinical feature.The prognosis of the patients is poor,so stem-cell transplantation maybe the only and the first choice of treatment.