Analysis of clinical pathological characteristics and prognosis of elderly patients with EB virus-positive diffuse large B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2014.04.004
- VernacularTitle:老年人EB病毒阳性弥漫大B细胞淋巴瘤临床病理学特点及预后分析
- Author:
Xuemin XUE
;
Zifen GAO
;
Xiaoyan WANG
;
Xin HUANG
;
Congyou GU
;
Cuiling LIU
;
Min LI
- Publication Type:Journal Article
- Keywords:
Lymphoma,large-cell,diffuse;
EB virus;
Pathology,clinical;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2014;23(4):204-207,212
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical pathological characteristics and prognosis of elderly patients with EB virus-positive diffuse large B-cell lymphoma (EBV+ DLBCL).Methods 24 elderly patients with EBV + DLBCL were collected to evaluate their clinical pathological characteristics and prognosis by comparison with the EBV-DLBCL,NOS during the same period.Results 24 EBV + DLBCL cases demonstrated two morphologic subtypes:polymorphic and monomorphic.And polymorphic subtype showed geographic necrosis more frequently than that in monomorphic subtype.According to Hans and Choi models,the majority of EBV+ DLBCL of the elderly were classified as non-GCB subtype (91.3 ％ and 100.0 ％,respectively).55.0 ％ cases showed CD30 positive,which was significantly higher than that in EBV-DLBCL group (P ＜ 0.001).Under the treatment of R-CHOP regimen,the overall survival (OS) of the elderly EBV+ DLBCL patients showed no significant difference with the ＞50-year old EBV-DLBCL patients (the median OS were 44.2 months and 29.2 months,P =0.587).Conclusions The elderly EBV + DLBCL patients are normally presented with polymorphic and monomorphic patterns.And geographic necrosis are often seen in polymorphic cases.CD30 expression and non-GCB subtypes are high.With the R-CHOP regimen,the OS of the elderly EBV+ DLBCL patients is similar with that of ＞50-year old EBV-DLBCL patients.
