Human immunodeficiency virus infection concurrent with acute promyelocytic leukemia and chronic myeloid leukemia: two cases report and literatures review
10.3760/cma.j.issn.1009-9921.2014.01.015
- VernacularTitle:人类免疫缺陷病毒感染合并急性早幼粒细胞白血病及慢性粒细胞白血病二例并文献复习
- Author:
Yun ZHOU
;
Chuanjun HE
;
Chunlong WU
;
Xiaoying XIE
;
Li MA
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
Leukemia,promyelocytic,acute;
Leukemia,myelogenous,chronic
- From:
Journal of Leukemia & Lymphoma
2014;23(1):45-47,52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinicopathologic features,effective therapeutic regimen and prognosis of human immunodeficiency virus (HIV) infection with acute promyelocytic leukemia (APL) and chronic myeloid leukemia (CML).Methods Two cases of HIV infection concurrent with leukemia,one with APL,one with CML,were studied and relevant literatures were reviewed.Results Case 1 was HIV infection concurrent with APL,ATO was used to induce remission,in the eight day of therapy,the patient died of brain disorder.Case 2 was HIV infection concurrent with CML,hydroxycarbamide and interferon were used to induce remission,three month later,state of an illness progressed to acute phase,after combination chemotherapy,concurrent with lung multiple infection (fungus and pneumocystis carinii),at last,the patient died of respiratory failure.Conclusion HIV infection concurrent with acute and chronic leukemia has poor therapeutic effect,and is easy to infect seriously.
