Anti-CD137 mAb Deletes Both Donor CD4+ and CD8+ T Cells in Acute Graft-versus-host Disease.
- Author:
Juyang KIM
1
;
Hong Rae CHO
;
Byungsuk KWON
Author Information
- Publication Type:Brief Communication
- Keywords: Rodent; T cells; Graft versus host disease; Costimulation
- MeSH: Cell Death; Graft vs Host Disease; Humans; Receptors, Tumor Necrosis Factor; Rodentia; T-Lymphocytes; Tissue Donors
- From:Immune Network 2011;11(6):428-430
- CountryRepublic of Korea
- Language:English
- Abstract: We previously demonstrated that in vivo engagement of CD137, a member of TNF receptor superfamily, can delete allorective CD4+ T cells through the induction of activation-induced cell death (AICD) in chronic graft-versus-host disease (cGVHD) and subsequently reverse established cGVHD. In this study, we further showed that agonistic anti-CD137 mAb was highly effective in triggering AICD of donor CD8+ T cells as well as donor CD4+ T cells in the C57BL/6-->unirradiated (C57BL/6 x DBA/2)F1 acute GVHD model. Our results suggest that strong allostimulation should facilitate AICD of both alloreactive CD4+ and CD8+ T cells induced by CD137 stimulation. Therefore, depletion of pathogenic T cells using agonistic anti-CD137 mAb combined with potent TCR stimulation may be used to block autoimmune or inflammatory diseases mediated by T cells.
