Interleukin-18 in early diagnosis of acute kidney injury after coronary artery bypass graft surgery
10.3760/cma.j.issn.1673-4203.2014.10.014
- VernacularTitle:白细胞介素-18早期诊断冠脉搭桥术后急性肾损伤的研究
- Author:
Yongsheng NIU
;
Cui ZHANG
;
Yinying XUE
;
Liang HONG
;
Xinwei MU
- Publication Type:Journal Article
- Keywords:
Interleukin-18;
Coronary artery bypass graft surgery;
Acute kidney injury
- From:
International Journal of Surgery
2014;41(10):690-693,封4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To test the hypothesis that interleukin-18 (IL-18) in the urine and serum sample are early biomarker for acute kidney injury (AKI) in patients after coronary artery bypass graft surgery (CABG).Methods Eighty patients who underwent CABG were recruited.The patients were divided into AKI group and non-AKI group according to the AKI criteria.The urine and serum sample were collected at pre-operation and 2 h,4 h,6 h,8 h,12 h,24 h after the CABG.The urine and serum IL-18 value were test by ELISA method.Receiver-operating characteristic cue(ORC) and the area under the cure(AUC) asses the sensitivity and specificity of IL-18 for AKI.Results Thirteen of eighty cases(16.25％) developed postoperative AKI according to the AKI criteria.Diagnosis with creatinine was only 24-48 hours after CABG.The serum and urinary concentrations of IL-18 at mostly each time point after CABG in AKI patients were significantly higher than those in non-AKI patients(P ＜ 0.01).Urinary and serous concentrations of IL-18 peaked at 4 h after CABG in AKI patients.ROC curve showed AUC in urinary and serous concentrations of IL-18 at 2 h ＞ 0.8 ; Concentrations of IL-18 in urine and serum at 2 h were the powerful independent predictors of AKI by logistic regression analysis.Conclusion IL-18 in urine and serum after CABG surgery were the powerful independent predictors of AKI.
