Evolution, differential diagnosis and intervention strategies of monoclonal gammopathy of undetermined significances:reports in the 54 ASH annual meeting
10.3760/cma.j.issn.1009-9921.2013.02.004
- VernacularTitle:意义未明的单克隆免疫球蛋白血症的病程演变、鉴别诊断及其干预策略:第54届美国血液学会年会报道
- Author:
Jianping LI
;
Jianming FENG
- Publication Type:Journal Article
- Keywords:
Monoclonal gammopathy of undetermined significances;
Smoldering multiple myeloma;
Multiple myeloma;
Amyloidosis;
ASH annual meeting
- From:
Journal of Leukemia & Lymphoma
2013;22(2):74-76,80
- CountryChina
- Language:Chinese
-
Abstract:
Monoclonal gammopathy of undetermined significances (MGUS) is a premalignant clonal disorder occurring in 4.2 ％ of adults ＞50 years old,and is associated with a 1％ risk every year of progression to multiple myeloma (MM),light-chain amyloidosis and related conditions.Differential diagnosis of asymptomatic and symptomatic monoclonal gammopathies is the determinant for starting therapy.Most patients with MGUS need frequent assessment and follow-up.A few patients with MGUS might progress into smoldering MM and symptomatic MM,or develop into light chain diseases such as AL amyloidosis and light chain deposition disease caused by M-protein,who should be followed with effective therapy.The above were in detail reviewed in the 54th American Society of Hematology (ASH) annual meetina.
