Efficacy of precise hyperthermic intraperitoneal perfusion chemotherapy in the treatment of advanced pancreatic cancer
10.3760/cma.j.issn.1008-1372.2014.10.007
- VernacularTitle:精确腹腔热灌注化疗治疗晚期胰腺癌的临床疗效观察
- Author:
Zulong CHEN
;
Yinbing WU
;
Hongsheng TANG
;
Zhiyuan FANG
;
Shuzhong CUI
- Publication Type:Journal Article
- Keywords:
Hyperthermia,induced;
Antineoplastic combined chemotherapy protocols/therapeutic use;
Abdominal cavity;
Infusions,parenteral;
Pancreatic neoplasms/therapy;
Treatment outcome
- From:
Journal of Chinese Physician
2014;16(10):1333-1335,1339
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of precise hyperthermic intraperitoneal perfusion chemotherapy (HIPEC) in the treatment of advanced pancreatic cancer.Methods Thirty-six patients with advanced pancreatic cancer were analyzed retrospectively.Eighteen patients who received HIPEC combined with radiotherapy and chemotherapy were assigned as the treatment group and the other 18 patients who received chemotherapy and radiotherapy were assigned as the control group.Recent curative efficacy,Karnofsky Performance Status (KPS) score,postoperative complications and survivals between the two groups were analyzed,respectively.Results Significant differences were found between two groups in total short-term effective rate (P ＜ 0.05).The total short-term effective rate of treatment group and control group were 66.67％ (12/18) and 27.78％ (5/18),respectively.The increment of KPS score of treatment group was significantly higher than that of control group (P ＜ 0.05).There was no significant difference between two groups in postoperative complications (P ＞ 0.05).The median overall survival time (OS) of treatment group was 11 months (7 ～ 31 months),and the median OS of control group was 7 months (4 ～ 18 months).The survival of the treatment group was longer than the control group (P ＜ 0.05).Conclusions HIPEC treatment improved significantly the survival and life quality of advanced pancreatic cancer patients.With acceptable morbidity and mortality rates,HIPEC regime was an effective treatment modality for patients with advanced pancreatic cancer.
