Research progress on regulation of angiotensin Ⅱ on bone metabolism
10.3969/j.issn.1001-1978.2015.04.004
- VernacularTitle:血管紧张素Ⅱ调控骨代谢的研究进展
- Author:
Jinxin LIU
;
Fangyi ZHANG
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
renin-angiotensin system;
angiotensin Ⅱ;
osteo-blasts;
osteoclasts;
osteoporosis;
receptor
- From:
Chinese Pharmacological Bulletin
2015;(4):458-460,461
- CountryChina
- Language:Chinese
-
Abstract:
The renin-angiotensin system exists locally in bone tissue.The RAS components and the active peptide angiotensinⅡ (Ang Ⅱ)within RAS are directly involved in the pathophysi-ological process of regulating bone metabolism.Ang Ⅱ exerts the effects via its receptors expressed in osteoblasts and osteoclasts. This paper reviewed the pathways of classical RAS,explained the tissue RAS-induced tissue injuries,and especially elaborated the regulation of RAS active peptide Ang Ⅱ on target genes and in-tracellular signaling pathways in osteoblasts,the action of Ang Ⅱon osteoclastic function via acting on osteoblasts,and the inter-action of Ang Ⅱ receptors involved in the modulation on bone metabolism.
