Clinical observation of chronic obstructive pulmonary disease with pulmonary heart disease by modified Dingchuan zhike decoction and ambroxol hydrochloride
10.3760/cma.j.issn.1008-6706.2015.08.003
- VernacularTitle:氨溴索联合定喘止咳汤治疗慢性阻塞性肺疾病合并慢性肺心病的临床观察
- Author:
Zheyan YU
;
Junquan ZHU
- Publication Type:Journal Article
- Keywords:
Ambroxol;
Dingchuan zhike decoction;
Chronic obstructive pulmonary disease;
Pulmonary heart disease
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(8):1127-1129,1130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical effects of Dingchuan zhike decoction with ambroxol hydrochlo-ride on the patients with chronic obstructive pulmonary disease and pulmonary heart disease.Methods According to the random number table,the patients were divided into the observation group (70 cases)and the control group (73 cases).The patients were treated with ambroxol hydrochloride and Dingchuan zhike decoction in the observation group;the control group had a treatment with ambroxol hydrochloride.The lung function,sputum fluid inflammatory cytokines and clinical symptoms were compared between the two groups.Results When the two groups received treatment for 7 days,VC and FEV1 in the observation group were (2.45 ±0.38)L and (1.51 ±0.24)L,those in the control group were (1.94 ±0.38)L,(1.01 ±0.21)L,the patients′lung functions:FVC,VC,PEF,FEV1,and MVV% were improved in the observation group than those in the control group (t=10.64,15.87,12.14,10.22, 14.04,all P<0.05);After 14 days treatment,VC and FEV1 of patients in observation group were (2.83 ±0.35)L and (1.67 ±0.27)L,those in control group were (2.25 ±0.22)L,(1.21 ±0.23)L,the patients in the observation group were better than those in the control group on the lung functions:FVC,VC,PEF,FEV1 ,and MVV% (t =11.02,11.87,12.68,16.41,16.09,all P<0.05).The CRP of the observation group were (14.13 ±5.21)mg/L, (3.94 ±2.39)mg/L,after 7 and 14 days treatment respectively.And these in the control group were (20.99 ±9.77) mg/L,(9.94 ±8.22)mg/L.The PCT of the observation group were (0.31 ±0.24)μg/L,(0.27 ±0.09)μg/L. These in the control group were (0.51 ±0.21)μg/L,(0.31 ±0.18)μg/L.The levels of CRP and PCT on the obser-vation group′patients were better than those on the control group′patients after 7 days treatment (t=16.75,22.05, all P<0.05).When patients received 14 days therapy,the levels of CRP and PCT on the observation group′patients were better than those on the control group′patients (t=10.75,12.05,all P<0.05).The total effective rate was 86.30% in the control group and that of the observation group was 97.14 %.The total effective in the observation group was better than that in the control group.(χ2 =5.46,P<0.05).Conclusion The therapy of ambroxol hydro-chloride with Dingchuan zhike decoction is better than therapy of ambroxol hydrochloride alone.
