Preparation and in vitro Drug Release of Sorafenib-Eudragit RS Nanoparticles
- VernacularTitle:索拉非尼-Eudragit RS 纳米粒的制备及理化性质研究
- Author:
Jia WEI
;
Zhang HONG
;
Zhang YING
- Publication Type:Journal Article
- Keywords:
Sorafenib;
Eudragit RS100;
üanoparticles;
Solvent-nonsolvent method;
Optimization;
In vitro release
- From:
China Pharmacist
2015;(4):541-544,554
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare and optimize sorafenib-Eudragit RS nanoparticles( S-E üPs)and investigate the physicochemi-cal properties. Methods:S-E üPs were prepared by a solvent-nonsolvent method. Single factor experiments were used to research the effect of solvent,stabilizer type,carrier ratio and the proportions of water phase and organic phase on the physicochemical properties of S-E üPs. S-E üPs were evaluated by the particle size,zeta potential and morphology,and the in vitro drug release of S-E üPs was studied using dialysis technology. Results:The mean size was(86. 72 ± 3. 71)nm,the PDI and zeta potential was(0. 20 ± 0. 032)and (36. 6 ± 0. 3)mV,respectively,S-E üPs showed spherical shape with uniform distribution. The drug release in vitro was accorded with a Weibull equation. Conclusion:The solvent-nonsolvent method is appropriate for the preparation of S-E üPs. The nanoparticles have small particle size,uniform distribution,regular morphology and significant sustained-release property.
